KMID : 0357920140480020117
|
|
Korean Journal of Pathology 2014 Volume.48 No. 2 p.117 ~ p.125
|
|
Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
|
|
Lee Eun-Jung
Jung Won-Kyung Woo Jeong-Soo Lee Jae-Bok Shin Bong-Kyung Kim Han-Kyeom Kim Ae-Ree
|
|
Abstract
|
|
|
Background: Identification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients¡¯ care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed this form of tumor clustering, ¡®tumor sprouting,¡¯ and determined whether these tumors correlate with lymphovascular invasion, lymph node metastasis, and recurrence.
Methods: We analyzed a total of 204 cases of papillary thyroid macrocarcinoma. Number, size and distance from the main tumor of the tumor sprouting were observed and analyzed with clinicopathologic characteristics.
Results: Tumor sprouting was observed in 101 patients. Presence of tumor sprouting was significantly associated with positive resection margin (p=.002), lymphovascular invasion (p=.001), lymph node metastasis (p<.001), and recurrence (p=.004). Univariate analysis of recurrence- free survival revealed that tumor multiplicity (p=.037), positive resection margin (p=.007), lymphovascular invasion (p=.004), lymph node metastasis (p<.001), and tumor sprouting (p=.004) were poor prognostic factors. In multivariate analysis, positive resection margin was an independent poor prognostic factor of recurrence.
Conclusions: In conclusion, tumor sprouting is significantly correlated with lymph node metastasis and recurrence. Evaluation of tumor sprouting in PTC patients could be helpful in predicting tumor recurrence or lymph node metastasis.
|
|
KEYWORD
|
|
Tumor sprouting, Thyroid cancer, papillary, Lymphatic invasion, Lymph node metastasis, Recurrence
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|